Association Of rs16260 Polymorphism Of CDH1 Gene With Recurrent Pregnancy Loss In Iranian-Azeri Women

Background & aim: Recurrent pregnancy loss is defined as loosing at least 2 pregnancies before 20th weeks of gestation. Besides all the known causative factors, in about half of the cases, the causing factor, remains unknown. In recent years, some studies have shown the role of candidate genes polymorphisms in RPL. CDH1 is one of these candidate genes that plays critical role in embryo implantation. The aim of this study is to evaluate the relation between rs16260 of this gene with RPL. Methods: This case-control study was conducted on 120 women with idiopathic RPL as case group and 120 healthy women without any history of infertility or abortion with at least one healthy child as the control group. These subjects were referred to a private genetic lab by a gynecologist. The polymorphism was studied using the amplification-refractory mutation system-polymerase chain reaction approach, and the obtained data were analyzed in SPSS software (version 26) using the chi-squared test (P˂0.05). Results: The frequencies of AA, AC and CC genotypes in the case group are 4(3.3%), 36(23.3%) and 76(73.4%) and in the control group are 8(6.7%), 28(30%) and 88(63.3%) respectively. P-Value=0.201 Conclusion: According to statistical analyzes there is not any association between this polymorphism and recurrent pregnancy loss in any of the statistical models.